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Research Technician

Job Description

Job ID:
39299

Location:
450 Brookline Ave, Boston, MA 02215

Category:
Research Laboratory

Employment Type:
Full time

Work Location:
Onsite: 100% onsite

Overview

The Center for Immuno-Oncology (CIO) at Dana-Farber Cancer Institute (DFCI) evalulates patient samples from immunotherapy clinical trials to identify biomarkers of response across many different cancer types.  The Tissue Biomarker Lab (TBL) is a research team within the CIO that performs detailed characterization of the tumor microenvironment using quantitative imaging assays (see https://ciopath.dfci.harvard.edu/ for more detail). With supervision from a Principal Scientist, the research technician will carry out quantitative, image-based spatial characterization of immune and cancer cells within patient biopsy samples.  The research technician will be expected to work both as part of a team and independently to determine the best approaches to perform the required analyses and to interpret resulting data.

The positions in this job family will assist scientists in performing scientific research, development and/or clinical tasks of varying complexity.  In general, they will assist in the set up, operation and maintenance of laboratory instruments and equipment, monitoring experiments, making observations and calculating and recording results.   

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

  • Perform technical procedures such as chromogenic immunohistochemistry, multiplex immunofluorescence, fluorescent in-situ hybridization, and prepare samples for advanced microscopic methods.
  • Develop and test new immunostaining assays, workflows and instruments for highly multiplexed analyses of cancer tissues.
  • Operate laboratory instruments and equipment, especially automated tissue stainers and multiplex fluorescence microscopes.
  • Develop and apply computer-based quantitative approaches to assess multiplex immunostained tissue samples utilizing commercial and custom image analysis software in collaboration with the TBL and computational biology teams.
  • Keep detailed records and maintain databases containing experimental results and reagent information.
  • Prepare and present written or oral progress reports describing studies and results, including assembly, organization and interpretation of data.
  • Order chemicals, reagents and other laboratory supplies.
  • May demonstrate and explain various laboratory techniques to laboratory personnel, students and others.
  • Perform all other duties and responsibilities as directed.

Qualifications

  • Bachelor's Degree required with a major in biology, chemistry, immunology, biophysics, or biomedical engineering is preferred.
  • Candidates with a background or experience in computational biology and engineering are encouraged to apply.
  • Experience working in a laboratory environment required.
  • Knowledge of either biology, chemistry, molecular biology, or biomedical research experimental approaches is required.
  • Understanding of how to apply quantitative approaches to scientific experiments is required, computer programming experience a plus.
  • Must have excellent written and verbal communication skills and be proactive in seeking answers to questions.
  • Must have excellent attention to detail and be thorough in completing tasks.
  • Ability to work within a team environment.
  • Willingness to spend 2-years, minimum, in the position.

KNOWLEDGE, SKILLS AND ABILITIES REQUIRED:

  • Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred.
  • Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
  • Ability to analyze information and use logic to address work-related issues and problems.
  • Must have attention to detail and be thorough in completing work tasks.
  • Ability to work within a team environment.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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